The MIME type application/x-Research-Info-Systems is used to denote the presence of ProCite and/or Reference Manager Citation files. This MIME type falls under the category of "application".

The ProCite and Reference Manager citation files use the same extension � RIS. These files carry the text necessary for citations. Both of these applications help with citations in scholarly texts and papers. These applications help the user search, index and store relevant citations using proprietary formats and databases. These applications are mainly used by scientists, researchers, professors, teachers and also students. The main features of these two applications are in the searching, indexing and organizing areas. These applications allow the user to search through multiple online databases, Internet libraries, as well as storage media such as diskettes and CD-ROM.

The keyword based advanced searching reduces the time required to search for citations from so many different sources. The automatic database building features of these applications ensure that data-entry is automated and optimized. All the sources used for searching can be harvested for relevant data. Advanced management features allow the user to properly group and separate citations in to more a personalized order. These applications are thus meant to speed up the process of finding and including citations by automating major aspects of the entire process.